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I can't tell the story of Wendy Schlessinger's efforts to get a refund from Rodan and Fields without also exploring the dark history of multilevel marketing (MLM). On the surface, Schlessinger's attempt to get her money back looks like an open-and-shut case. Maybe it's just an innocent error made by a $4 billion skincare company. Then again, maybe it's part of a business strategy that includes pushing pricey subscriptions on unwitting consumers. Multilevel marketing schemes have touched more than one of our readers. Chances are, you've run across products that were aggressively marketed through these methods. I have, and I'll tell you my embarrassing story in just a moment. Schlessinger's case left me not only sad, but furious. It involved Rodan and Fields sending products she says she didn't order, a destroyed friendship, a denied request for a refund, and a credit card dispute that the company fought — even though it knew it was wrong. But is t...
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Shedding of N-acetylglucosaminyltransferase-V is regulated by ... - Nature.com

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Abstract The number of N -glycan branches on glycoproteins is closely related to the development and aggravation of various diseases. Dysregulated formation of the branch produced by N -acetylglucosaminyltransferase-V (GnT-V, also called as MGAT5) promotes cancer growth and malignancy. However, it is largely unknown how the activity of GnT-V in cells is regulated. Here, we discover that the activity of GnT-V in cells is selectively upregulated by changing cellular N -glycans from mature to immature forms. Our glycomic analysis further shows that loss of terminal modifications of N -glycans resulted in an increase in the amount of the GnT-V-produced branch. Mechanistically, shedding (cleavage and extracellular secretion) of GnT-V mediated by signal peptide peptidase-like 3 (SPPL3) protease is greatly inhibited by blocking maturation of cellular N -glycans, resulting in an increased level of GnT-V protein in cells. Alteration of cellular N -glycans hardly impairs expression or localizati...
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